Frontiers - Immunology
@FrontImmunol
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Research and updates from all @FrontiersIn journals in the field of immunology. #openaccess
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Follow along for the latest research, updates and news from all
@FrontiersIn
journals in the field of immunology 👀
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World-class research + Open Access = new breakthroughs, faster. Congratulations to all authors, reviewers & editors for powering our knowledge-driven world!
See your impact:
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70 million article views and downloads. 👁
From research and innovation hubs around the world. 🌎
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Frontiers supports the
@KeystoneSymp
virtual meeting "Myeloid Cells and Innate Immunity in Solid Tumors" (21-23 Sep).
#eSymposia
#VKSmyeloidintumors21
#MyeloidCells
#InnateImmunity
Looking forward to attending the event!
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New Research: Flow cytometric analysis of innate lymphoid cells: challenges and solutions: Introduction
The three groups of helper innate lymphoid cells (ILCs), namely ILC1, ILC2 and ILC3, have been identified by flow cytometry by…
#immunology
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Working with the academic community to transform how science is published, evaluated, and communicated.
Join us on this mission today and make your impact.
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New Research: DAMPs and Innate Immune Training: The ability to remember a previous encounter with pathogens was long thought to be a key feature of the adaptive immune system enabling the host to mount a faster, more specific and more…
#immunology
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New Research: Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies: Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is the pathogen that causes coronavirus disease 2019 (COVID-19). As of 25 May 2020, the…
#immunology
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New Research: Neutrophils: Need for Standardized Nomenclature: Neutrophils are the most abundant innate immune cell with critical anti-microbial functions. Since the discovery of granulocytes at the end of the nineteenth century, the cells…
#immunology
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New Research: γδ T Cells in the Tumor Microenvironment—Interactions With Other Immune Cells: A growing number of studies have shown that γδ T cells play a pivotal role in mediating the clearance of tumors and pathogen-infected cells with…
#immunology
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New Research: A Comprehensive Atlas of Immunological Differences Between Humans, Mice, and Non-Human Primates: Animal models are an integral part of the drug development and evaluation process. However, they are unsurprisingly imperfect…
#immunology
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New Research: Systemic virus infection results in CD8 T cell recruitment to the retina in the absence of local virus infection: During recent years, evidence has emerged that immune privileged sites such as the CNS and the retina may be more…
#immunology
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New Research: CAR-NK cells for cancer immunotherapy: recent advances and future directions: Natural Killer (NK) cells, intrinsic to the innate immune system, are pivotal in combating cancer due to their independent cytotoxic capabilities in…
#immunology
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New Research: Gut Microbiota, Leaky Gut, and Autoimmune Diseases: With the rising prevalence of autoimmune diseases, the role of the environment, specifically the gut microbiota, in disease development has grown to be a major area of study.…
#immunology
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New Research: IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology: The barrier surfaces of the gastrointestinal tract are in constant contact with various microorganisms. Cytokines orchestrate the mucosal adaptive and innate…
#immunology
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New Research: CD3+CD4-CD8- (Double-Negative) T Cells in Inflammation, Immune Disorders and Cancer: The crucial role of CD4+ and CD8+ T cells in shaping and controlling immune responses during immune disease and cancer development has been…
#immunology
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New Research: Mitochondrial extracellular vesicles, autoimmunity and myocarditis: For many decades viral infections have been suspected as ‘triggers’ of autoimmune disease, but mechanisms for how this could occur have been difficult to…
#immunology
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New Research: T cell memory in infection, cancer, and autoimmunity: Long-term immunological memory represents a unique performance of the adaptive immunity selected during evolution to support long-term survival of species in vertebrates by…
#immunology
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New Research: A Flow Cytometry-Based Whole Blood Natural Killer Cell Cytotoxicity Assay Using Overnight Cytokine Activation: Background: Measurement of natural killer (NK) cell function has important clinical utility in several diseases.…
#immunology
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New Research: Making a Killer: Selecting the Optimal Natural Killer Cells for Improved Immunotherapies: Over the past 20 years natural killer (NK) cell-based immunotherapies have emerged as a safe and effective treatment option for patients…
#immunology
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New Research: Advances in reprogramming of energy metabolism in tumor T cells: Cancer is a leading cause of human death worldwide, and the modulation of the metabolic properties of T cells employed in cancer immunotherapy holds great promise…
#immunology
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New Research: The cellular composition of the tumor microenvironment is an important marker for predicting therapeutic efficacy in breast cancer: At present, the incidence rate of breast cancer ranks first among new-onset malignant tumors in…
#immunology
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New Research: mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment: The mechanistic/mammalian target of rapamycin (mTOR) is a downstream mediator in the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways,…
#immunology
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New Research: Transcriptional Analysis of Total CD8+ T Cells and CD8+CD45RA- Memory T Cells From Young and Old Healthy Blood Donors: Memory CD8+ T cells accumulate with aging, while the naïve T cell compartment decreases, leading to an…
#immunology
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New Research: The paradigm of IL-23-independent production of IL-17F and IL-17A and their role in chronic inflammatory diseases: Interleukin-17 family (IL-17s) comprises six structurally related members (IL-17A to IL-17F); sequence homology…
#immunology
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New Research: SARS-CoV-2 Antibodies Are Persisting in Saliva for More Than 15 Months After Infection and Become Strongly Boosted After Vaccination: SARS-CoV-2 antibodies in saliva serve as first line of defense against the virus. They are…
#immunology
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New Research: NK cell exhaustion in the tumor microenvironment: Natural killer (NK) cells kill mutant cells through death receptors and cytotoxic granules, playing an essential role in controlling cancer progression. However, in the tumor…
#immunology
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New Research: Epigenetic Changes Associated With Interleukin-10: IL-10 is a regulator of inflammation and immunosuppression. IL-10 regulates a variety of immune cells to limit and stop the inflammatory response, and thus plays an important…
#immunology
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New Research: The Expanding Arsenal of Cytotoxic T Cells: Cytotoxic T cells (CTLs) are the main cellular mediators of the adaptive immune defenses against intracellular pathogens and malignant cells. Upon recognition of specific antigen on…
#immunology
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New Research: Interferon lambda in respiratory viral infection: immunomodulatory functions and antiviral effects in epithelium: Type III interferon (IFN-λ), a new member of the IFN family, was initially considered to possess antiviral…
#immunology
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New Research: Autoimmunity and Cancer—Two Sides of the Same Coin: Autoimmune disease results from the immune response against self-antigens, while cancer develops when the immune system does not respond to malignant cells. Thus, for years,…
#immunology
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New Research: Regulatory T Cells in Autoimmune Vasculitis: Blood vessels are indispensable for host survival and are protected from inappropriate inflammation by immune privilege. This protection is lost in patients with autoimmune…
#immunology
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New Research: Lessons Learned to Date on COVID-19 Hyperinflammatory Syndrome: Considerations for Interventions to Mitigate SARS-CoV-2 Viral Infection and Detrimental Hyperinflammation: The first case of human transmission of SARS-CoV-2 was…
#immunology
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Frontiers in Immunology ranks among the world's top 10 most-cited
#Immunology
journals. See the full journal impact analysis here:
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New Research: IgG4 autoantibodies and autoantigens in the context of IgG4-autoimmune disease and IgG4-related disease: Immunoglobulins are an essential part of the humoral immune response. IgG4 antibodies are the least prevalent subclass and…
#immunology
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New Research: Mechanisms of MHC-I Downregulation and Role in Immunotherapy Response: Immunotherapy has become a key therapeutic strategy in the treatment of many cancers. As a result, research efforts have been aimed at understanding…
#immunology
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New Research: Type III Interferons: Emerging Roles in Autoimmunity: Type III interferons (IFNs) or the lambda IFNs (IFNLs or IFN-λs) are antimicrobial cytokines that play key roles in immune host defense at endothelial and epithelial…
#immunology
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New Research: PD-1 and PD-L1: architects of immune symphony and immunotherapy breakthroughs in cancer treatment: PD-1 (Programmed Cell Death Protein-1) and PD-L1 (Programmed Cell Death Ligand-1) play a crucial role in regulating the immune…
#immunology
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Published in Frontiers in
#Immunology
: "Chimeric
#Antigen
Receptor Expressing Natural Killer
#Cells
for the
#Immunotherapy
of
#Cancer
" by Katayoun Rezvani & Rohtesh S. Mehta
Free download:
#aai2019
#immunology2019
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New Research: Innovative Strategies to Improve the Clinical Application of NK Cell-Based Immunotherapy: Natural killer cells constitute a part of the innate immune system that mediates an effective immune response towards virus-infected and…
#immunology
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New Research: Stretching the Function of Innate Immune Cells: The importance of innate immune cells to sense and respond to their physical environment is becoming increasingly recognized. Innate immune cells (e.g. macrophages and neutrophils)…
#immunology
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New Research: Targeting tumor-infiltrating tregs for improved antitumor responses: Immunotherapies have revolutionized the landscape of cancer treatment. Regulatory T cells (Tregs), as crucial components of the tumor immune environment, has…
#immunology
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New Research: Monocytes and Macrophages in COVID-19: COVID-19 is a contagious viral disease caused by SARS-CoV-2 that led to an ongoing pandemic with massive global health and socioeconomic consequences. The disease is characterized…
#immunology
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New Research: Regulatory T Cell Heterogeneity in the Thymus: Impact on Their Functional Activities: Foxp3+ regulatory T cells (Treg) maintain the integrity of the organism by preventing excessive immune responses. These cells protect against…
#immunology
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New Research: NF-κB: At the Borders of Autoimmunity and Inflammation: The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory response. In the first…
#immunology
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New Research: Metabolic Reprogramming in CD8+ T Cells During Acute Viral Infections: CD8+ T cells represent one of the most versatile immune cells critical for clearing away viral infections. Due to their important role, CD8+ T cell…
#immunology
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Led by Dr. Dario S. Zamboni
@ZamboniLab
of
@usponline
, our new specialty section
#Parasite
#Immunology
aims to advance our knowledge on immunity to parasites, as well as investigate parasite-specific strategies to subvert
#hostimmunity
. Learn more ⬇
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New Research: Post-Translational Modifications of STING: A Potential Therapeutic Target: Stimulator of interferon genes (STING) is an endoplasmic-reticulum resident protein, playing essential roles in immune responses against microbial…
#immunology
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New Research: Nature vs. nurture: FOXP3, genetics, and tissue environment shape Treg function: The importance of regulatory T cells (Tregs) in preventing autoimmunity has been well established; however, the precise alterations in Treg…
#immunology
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New Research: Unlocking the Role of Exercise on CD4+ T Cell Plasticity: A hallmark of T cell ageing is a loss of effector plasticity. Exercise delays T cell ageing, yet the mechanisms driving the effects of exercise on T cell biology are not…
#immunology
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New Research: A four-part guide to lung immunology: Invasion, inflammation, immunity, and intervention: Lungs are important respiratory organs primarily involved in gas exchange. Lungs interact directly with the environment and their primary…
#immunology
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New Research: Cancer cells and viruses share common glycoepitopes: exciting opportunities toward combined treatments: Aberrant glycosylation patterns of glycoproteins and glycolipids have long been recognized as one the major hallmarks of…
#immunology
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New Research: When Immunity Kills: The Lessons of SARS-CoV-2 Outbreak: Since its emergence at the end of 2019, SARS-CoV-2 has spread worldwide at a very rapid pace. While most infected individuals have an asymptomatic or mild disease, a…
#immunology
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New Research: STING Signaling and Sterile Inflammation: Innate immunity is regulated by a broad set of evolutionary conserved receptors to finely probe the local environment and maintain host integrity. Besides pathogen recognition through…
#immunology
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New Research: The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier: The skin barrier would not function without IL-1 family members, but their physiological role in the immunological aspects of skin barrier function are…
#immunology
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New Research: Dendritic cells: the yin and yang in disease progression: Dendritic cells (DCs) are antigen presenting cells that link innate and adaptive immunity. DCs have been historically considered as the most effective and potent cell…
#immunology
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New Research: Characterization of CD4+ and CD8+ T cells responses in the mixed lymphocyte reaction by flow cytometry and single cell RNA sequencing: Background
The Mixed Lymphocyte Reaction (MLR) consists in the allogeneic co-culture of…
#immunology
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New Research: Plasticity of NK cells in Cancer: Natural killer (NK) cells are crucial to various facets of human immunity and function through direct cytotoxicity or via orchestration of the broader immune response. NK cells exist across a…
#immunology
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New Research: Adaptor molecules mediate negative regulation of macrophage inflammatory pathways: a closer look: Macrophages play a central role in initiating, maintaining, and terminating inflammation. For that, macrophages respond to various…
#immunology
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New Research: Vascular Microenvironment, Tumor Immunity and Immunotherapy: Immunotherapy holds great promise for treating cancer. Nonetheless, T cell-based immunotherapy of solid tumors has remained challenging, largely due to the lack of…
#immunology
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New Research: Skin immunity in wound healing and cancer: The skin is the body’s largest organ. It serves as a barrier to pathogen entry and the first site of immune defense. In the event of a skin injury, a cascade of events including…
#immunology
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New Research: Immune checkpoint inhibitors associated cardiovascular immune-related adverse events: Immune checkpoint inhibitors (ICIs) are specialized monoclonal antibodies (mAbs) that target immune checkpoints and their ligands,…
#immunology
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New Research: 29-Color Flow Cytometry: Unraveling Human Liver NK Cell Repertoire Diversity: Recent studies have demonstrated extraordinary diversity in peripheral blood human natural killer (NK) cells and have suggested environmental control…
#immunology
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New Research: The Adipose Tissue Macrophages Central to Adaptive Thermoregulation: White fat stores excess energy, and thus its excessive expansion causes obesity. However, brown and beige fat, known as adaptive thermogenic fat, dissipates…
#immunology
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New Research: Autoantigen Discovery in the Hair Loss Disorder, Alopecia Areata: Implication of Post-Translational Modifications: Alopecia areata (AA) is a chronic, multifactorial, polygenic, and heterogeneous disorder affecting growing hair…
#immunology
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Learn more about the pro- and antitumorigenic effects of IFN-γ in Tumor
#ImmuneSurveillance
or Evasion
Read & download
#openaccess
the review by Castro et al. at
#immunoregulation
#immunotherapy
#immunology
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New Research: Editorial: Next generation B cell targeting therapies in autoimmune diseases
#immunology
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New Research: Toll-Like Receptor Evolution: Does Temperature Matter?: Toll-like receptors (TLRs) recognize conserved pathogen-associated molecular patterns (PAMPs) and are an ancient and well-conserved group of pattern recognition receptors…
#immunology
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New Research: Immune cell networking in solid tumors: focus on macrophages and neutrophils: The tumor microenvironment is composed of tumor cells, stromal cells and leukocytes, including innate and adaptive immune cells, and represents an…
#immunology
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New Research: Alarmin Cytokines as Central Regulators of Cutaneous Immunity: Skin acts as the primary interface between the body and the environment. The skin immune system is composed of a complex network of immune cells and factors that…
#immunology
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New Research: The Role of Metabolic Dysfunction in T-Cell Exhaustion During Chronic Viral Infection: T cells are important components of adaptive immunity that protect the host against invading pathogens during infection. Upon recognizing the…
#immunology
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New Research: An Artifact in Intracellular Cytokine Staining for Studying T Cell Responses and Its Alleviation: Intracellular cytokine staining (ICS) is a widely employed ex vivo method for quantitative determination of the activation status…
#immunology
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New Research: Proinflammatory mucosal-associated invariant CD8+ T cells react to gut flora yeasts and infiltrate multiple sclerosis brain: The composition of the intestinal microbiota plays a critical role in shaping the immune system. Modern…
#immunology
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New Research: Epstein-Barr virus: the mastermind of immune chaos: The Epstein-Barr virus (EBV) is a ubiquitous human pathogen linked to various diseases, including infectious mononucleosis and multiple types of cancer. To control and…
#immunology
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New Research: Potentiation of natural killer cells to overcome cancer resistance to NK cell-based therapy and to enhance antibody-based immunotherapy: Natural killer (NK) cells are cellular components of the innate immune system that can…
#immunology
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New Research: Precursor exhausted CD8+T cells in colorectal cancer tissues associated with patient’s survival and immunotherapy responsiveness: Exhausted CD8+T cells represent a distinct cellular lineage that emerges during both chronic…
#immunology
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New Research: Metabolic regulation of T cell development: T cell development in the thymus is tightly controlled by complex regulatory mechanisms at multiple checkpoints. Currently, many studies have focused on the transcriptional and…
#immunology
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New Research: Targeting Microglial α-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson’s Disease: According to emerging studies, the excessive activation of microglia and the subsequent release of pro-inflammatory cytokines play…
#immunology
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New Research: Thyroid function and associated mood changes after COVID-19 vaccines in patients with Hashimoto thyroiditis: Context
Severe acute respiratory syndrome-coronavirus 2 (COVID-19) vaccines may incur changes in thyroid functions…
#immunology
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New Research: Strategies to reinvigorate exhausted CD8+ T cells in tumor microenvironment: CD8+ T cell exhaustion is a stable dysfunctional state driven by chronic antigen stimulation in the tumor microenvironment (TME). Differentiation of…
#immunology
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New Research: Neutrophil Extracellular Trap Induced Dendritic Cell Activation Leads to Th1 Polarization in Type 1 Diabetes: Neutrophils releasing neutrophil extracellular traps (NETs) infiltrate the pancreas prior to type 1 diabetes (T1D)…
#immunology
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New Research: Bacteria-based immunotherapy for cancer: a systematic review of preclinical studies: Immunotherapy has been emerging as a powerful strategy for cancer management. Recently, accumulating evidence has demonstrated that…
#immunology
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New Research: Novel and potential future therapeutic options in systemic autoimmune diseases: Autoimmune inflammation is caused by the loss of tolerance to specific self-antigens and can result in organ-specific or systemic disorders.…
#immunology
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New Research: Intestinal Stem Cell-on-Chip to Study Human Host-Microbiota Interaction: The gut is a tubular organ responsible for nutrient absorption and harbors our intestinal microbiome. This organ is composed of a multitude of specialized…
#immunology
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New Research: The role of tissue-resident memory T cells as mediators for response and toxicity in immunotherapy-treated melanoma—two sides of the same coin?: Tissue-resident memory T cells (TRM cells) have become an interesting subject of…
#immunology
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New Research: Association of the Microbiota and Pancreatic Cancer: Opportunities and Limitations: The human body is thoroughly colonized by a wide variety of microorganisms, termed microbiota. Pancreatic cancer, one of the most aggressive…
#immunology
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New Research: The Era of Cytotoxic CD4 T Cells: In 1986, Mosmann and Coffman identified 2 functionally distinct subsets of activated CD4 T cells, Th1 and Th2 cells, being key in distinct T cell mediated responses. Over the past three decades,…
#immunology
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New Research: Exhausted T cells hijacking the cancer-immunity cycle: Assets and liabilities: T cell exhaustion is an alternative differentiation path of T cells, sometimes described as a dysfunction. During the last decade, insights of T cell…
#immunology
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New Research: Impact of structural modifications of IgG antibodies on effector functions: Immunoglobulin G (IgG) antibodies are a critical component of the adaptive immune system, binding to and neutralizing pathogens and other foreign…
#immunology
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New Research: Molecular and Cellular Mechanisms Modulating Trained Immunity by Various Cell Types in Response to Pathogen Encounter: The induction of trained immunity represents an emerging concept defined as the ability of innate immune…
#immunology
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New Research: Single-cell RNA sequencing reveals cell type-specific immune regulation associated with human neuromyelitis optica spectrum disorder: Introduction
One rare type of autoimmune disease is called neuromyelitis optica spectrum…
#immunology
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New Research: Role of Toll-Like Receptors in Neuroimmune Diseases: Therapeutic Targets and Problems: Toll-like receptors (TLRs) are a class of proteins playing a key role in innate and adaptive immune responses. TLRs are involved in the…
#immunology
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New Research: Bi-specific autoantigen-T cell engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases: Introduction
In autoimmune diseases, autoreactive B cells comprise only the 0.1-0.5% of total…
#immunology
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New Research: The Era of Thromboinflammation: Platelets Are Dynamic Sensors and Effector Cells During Infectious Diseases: Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of literature supports the…
#immunology
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New Research: Neuroinflammation in epileptogenesis: from pathophysiology to therapeutic strategies: Epilepsy is a group of enduring neurological disorder characterized by spontaneous and recurrent seizures with heterogeneous etiology,…
#immunology
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A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation: Niamh C. Williams, Luke A. J. O’Neill
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New Research: Next Generation Natural Killer Cells for Cancer Immunotherapy: In recent years, immunotherapy for cancer has become mainstream with several products now authorized for therapeutic use in the clinic and are becoming the standard…
#immunology
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New Research: The Road Less Taken: Less Appreciated Pathways for Manipulating CD8+ T Cell Exhaustion: Exhausted CD8+ T (Tex) cells are a distinct cell population that arise during persistent antigen exposure in the context of chronic…
#immunology
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New Research: Cancer Associated Fibroblasts - An Impediment to Effective Anti-Cancer T Cell Immunity: The presence of functionally efficient cytotoxic T lymphocytes (CTL) in the Tumour nest is crucial in mediating a successful immune response…
#immunology
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